Phylloquinone
Solid evidence for essential for blood clotting. Not a miracle worker, but genuinely useful for the right person.
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Verdict
7/10 Solid
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Evidence
Grade B / 100+ Studies
Essential for blood clottingSupports bone mineralizationActivates osteocalcin for calcium depositionRequired for normal wound healing
Norans Kepals, Independent Researcher & Supplement Expert
March 1, 2026
The No-BS Summary
8 things. 60 seconds. Everything you need.
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WHAT IT DOES
The plant form of vitamin K that keeps your blood clotting properly and helps calcium get into your bones.
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DOES IT WORK?
Good pick. Phylloquinone is vitamin K1, the form found in green leafy vegetables. It's essential for blood clotting (activates clotting factors II, VII, IX, X) and bone mineralization (activates osteocalcin). Most people get enough from diet, but supplementation benefits those on restricted diets or taking certain medications. K2 (menaquinone) gets more hype for bone health, but K1 still does important work. Essential vitamin with a clear role.
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HOW MUCH TO TAKE
90-120 mcg daily
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COST
Budget-friendly. $20-35/month for quality brands.
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FIRST 24 HOURS
Don't expect miracles on day one. It's building in your system.
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AFTER A FEW WEEKS
Most people notice something by week 2-3.
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SAFETY
Few things to check: critical: interacts with warfarin/coumadin (keep intake consistent), fat-soluble, requires dietary fat for absorption. Worth mentioning to your doc.
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HOW IT FEELS
Effects vary person to person. Give it time.
2The Breakdown
Quick Answers
Dose-Response Curve
How effective is phylloquinone at different doses? Here's what the research shows.
Effectiveness %
0
25
50
75
100
MIN 90mg
SWEET SPOT 120mg
PLATEAU 500mg
Dose (mcg)
0-69%
Sub-therapeutic
<90mg
69-80%
Effective
90mg-120mg
~80%
Optimal
120mg
80%
Diminishing
>500mg
Moderate confidenceBased on clinical data + estimates
Source: IOM DRI 2001; Booth, 2012Bottom line: Most research uses 120mg daily. Below 90mg, you're probably wasting money. Above 500mg, you're not getting extra benefit.
Dosing Guide
When
As directed
How
90-120 mcg daily
Food
With or without food
Onset & Feel
Builds Over Time
Effects vary
Effects vary person to person. Give it time.
Cycle
As needed
How to Take It
Phylloquinone comes in several formats. Pick what fits your lifestyle.
Capsules/Tablets
Pre-measured doses, easy to take.
✓ Convenient✓ No taste✓ Portable✗ More expensive✗ May need multiple
Powder
Mix with water or a shake.
✓ Cheapest✓ Flexible dosing✗ Needs mixing✗ Taste varies
Softgels
Oil-based for fat-soluble nutrients.
✓ Better absorption for fats✓ No taste✗ Larger pills
Pick this:
Capsules for convenience, powder for value.
Skip this:
Check for unnecessary fillers and additives.
Delivery affects convenience and cost, not usually effectiveness.
Did you know?
Many studies and counting.
Heads Up
Generally safe at recommended doses. Talk to your doc if you have concerns. Check with your doc if: CRITICAL: Interacts with warfarin/Coumadin (keep intake consistent), Fat-soluble, requires dietary fat for absorption, K2 may be more effective for bone health specifically.
3Deep Dive
The Science, Simplified
For those who want the full picture
Phylloquinone has emerging evidence.
Trust Signals
Grade B
Evidence
50+
Studies
30
Human Trials
0
Meta-analyses
👍 Strong evidence. Most claims hold up under scrutiny.
Mechanism of Action
Acts as a cofactor for gamma-glutamyl carboxylase, which activates vitamin K-dependent proteins including clotting factors (prothrombin, factors VII, IX, X) and osteocalcin (bone mineralization).
Research Summary
Scientific consensus: undefined/10.
Consensus: /10STRONG Evidence
Origins & Manufacturing
Where does phylloquinone come from? Let's get nerdy.
How It's Made
Manufacturing process varies by supplier.
What to Look For
✓ Third-party tested✓ GMP certified
Drug & Supplement Interactions
4For You
Is Phylloquinone right for YOU?
Get a personalized verdict based on your health profile.
Products with Phylloquinone
Supplements that contain this ingredient
Medical Disclaimer
This content is for informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any supplement regimen, especially if you have medical conditions or take medications. ARE Supplements does not endorse any specific products.