Licorice
Solid evidence for soothes stomach ulcers and heartburn (dgl form). Not a miracle worker, but genuinely useful for the right person.
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Verdict
7/10 Solid
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Evidence
Grade B / 100+ Studies
Soothes stomach ulcers and heartburn (DGL form)Anti-inflammatory comparable to mild cortisoneSupports adrenal function
Norans Kepals, Independent Researcher & Supplement Expert
March 1, 2026
The No-BS Summary
8 things. 60 seconds. Everything you need.
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WHAT IT DOES
A potent anti-inflammatory root that soothes the gut and supports adrenal function. Powerful but needs respect.
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DOES IT WORK?
Good pick. Licorice root (Glycyrrhiza glabra) is one of the most well-researched herbs globally. Glycyrrhizin is a powerful anti-inflammatory, and the root has proven benefits for stomach ulcers, sore throat, and adrenal support. DGL (deglycyrrhizinated) form is great for gut health without blood pressure concerns. Just don't overdo the full-strength version.
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HOW MUCH TO TAKE
200-600 mg extract (or 380-760 mg DGL before meals)
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COST
Budget-friendly. $20-35/month for quality brands.
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FIRST 24 HOURS
Don't expect miracles on day one. It's building in your system.
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AFTER A FEW WEEKS
Most people notice something by week 2-3.
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SAFETY
Few things to check: full-strength licorice can raise blood pressure significantly, don't use for more than 4-6 weeks continuously. Worth mentioning to your doc.
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HOW IT FEELS
Effects vary person to person. Give it time.
2The Breakdown
Quick Answers
Dose-Response Curve
How effective is licorice at different doses? Here's what the research shows.
Effectiveness %
0
25
50
75
100
MIN 200mg
SWEET SPOT 450mg
PLATEAU 900mg
Dose (mg)
0-48%
Sub-therapeutic
<200mg
48-80%
Effective
200mg-450mg
~80%
Optimal
450mg
80%
Diminishing
>900mg
Moderate confidenceBased on clinical data + estimates
Source: Armanini D et al. Exp Clin Endocrinol Diabetes. 2002;110(6):257-261Bottom line: Most research uses 450mg daily. Below 200mg, you're probably wasting money. Above 900mg, you're not getting extra benefit.
Dosing Guide
When
As directed
How
200-600 mg extract (or 380-760 mg DGL before meals)
Food
With or without food
Onset & Feel
Builds Over Time
Effects vary
Effects vary person to person. Give it time.
Cycle
As needed
How to Take It
Licorice comes in several formats. Pick what fits your lifestyle.
Capsules/Tablets
Pre-measured doses, easy to take.
✓ Convenient✓ No taste✓ Portable✗ More expensive✗ May need multiple
Powder
Mix with water or a shake.
✓ Cheapest✓ Flexible dosing✗ Needs mixing✗ Taste varies
Softgels
Oil-based for fat-soluble nutrients.
✓ Better absorption for fats✓ No taste✗ Larger pills
Pick this:
Capsules for convenience, powder for value.
Skip this:
Check for unnecessary fillers and additives.
Delivery affects convenience and cost, not usually effectiveness.
Did you know?
Many studies and counting.
Heads Up
Generally safe at recommended doses. Talk to your doc if you have concerns. Check with your doc if: Full-strength licorice can raise blood pressure significantly, Don't use for more than 4-6 weeks continuously, Avoid with hypertension, heart disease, or kidney disease.
3Deep Dive
The Science, Simplified
For those who want the full picture
Licorice has emerging evidence.
Trust Signals
Grade B
Evidence
50+
Studies
30
Human Trials
0
Meta-analyses
👍 Strong evidence. Most claims hold up under scrutiny.
Mechanism of Action
Glycyrrhizin inhibits 11-beta-hydroxysteroid dehydrogenase type 2, extending cortisol's half-life (anti-inflammatory but raises blood pressure). DGL form removes glycyrrhizin, keeping the mucosal-protective flavonoids. Glabridin has estrogen-like and antioxidant activities.
Research Summary
Scientific consensus: undefined/10.
Consensus: /10STRONG Evidence
Origins & Manufacturing
Where does licorice come from? Let's get nerdy.
How It's Made
Manufacturing process varies by supplier.
What to Look For
✓ Third-party tested✓ GMP certified
Drug & Supplement Interactions
4For You
Is Licorice right for YOU?
Get a personalized verdict based on your health profile.
Products with Licorice
Supplements that contain this ingredient
Medical Disclaimer
This content is for informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any supplement regimen, especially if you have medical conditions or take medications. ARE Supplements does not endorse any specific products.