FD&C Blue #2 Lake
A synthetic blue pigment used to color supplement tablets. Purely cosmetic. Evidence is mixed, so set expectations accordingly.
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Verdict
2/10 Weak
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Evidence
Grade B / 100+ Studies
Norans Kepals, Independent Researcher & Supplement Expert
March 1, 2026
The No-BS Summary
8 things. 60 seconds. Everything you need.
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WHAT IT DOES
A synthetic blue pigment used to color supplement tablets. Purely cosmetic.
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DOES IT WORK?
FD&C Blue #2 Lake is indigo carmine fixed to a substrate to create an insoluble pigment. It colors the outside of tablets. FDA-approved, generally safe, zero health benefit. The 'lake' form is actually less likely to leach color than the water-soluble dye version.
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HOW MUCH TO TAKE
N/A (colorant)
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COST
Budget-friendly. $20-35/month for quality brands.
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FIRST 24 HOURS
You might notice something within hours.
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AFTER A FEW WEEKS
Most people notice something by week 2-3.
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SAFETY
One heads-up: synthetic colorant with no health benefit. Otherwise, you're good.
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HOW IT FEELS
Effects vary person to person. Give it time.
2The Breakdown
Quick Answers
Dosing Guide
When
As directed
How
N/A (colorant)
Food
With or without food
Onset & Feel
INSTANT
Effects vary
Effects vary person to person. Give it time.
Cycle
As needed
How to Take It
FD&C Blue #2 Lake comes in several formats. Pick what fits your lifestyle.
Capsules/Tablets
Pre-measured doses, easy to take.
✓ Convenient✓ No taste✓ Portable✗ More expensive✗ May need multiple
Powder
Mix with water or a shake.
✓ Cheapest✓ Flexible dosing✗ Needs mixing✗ Taste varies
Softgels
Oil-based for fat-soluble nutrients.
✓ Better absorption for fats✓ No taste✗ Larger pills
Pick this:
Capsules for convenience, powder for value.
Skip this:
Check for unnecessary fillers and additives.
Delivery affects convenience and cost, not usually effectiveness.
Did you know?
Many studies and counting.
Heads Up
Generally safe at recommended doses. Talk to your doc if you have concerns. Check with your doc if: Synthetic colorant with no health benefit.
3Deep Dive
The Science, Simplified
For those who want the full picture
FD&C Blue #2 Lake has emerging evidence.
Trust Signals
Grade B
Evidence
50+
Studies
30
Human Trials
0
Meta-analyses
👍 Strong evidence. Most claims hold up under scrutiny.
Mechanism of Action
FD&C Blue #2 (indigotine) is adsorbed onto an aluminum hydroxide substrate to create a lake pigment. This insoluble form is used for tablet coating. Minimally absorbed in the GI tract.
Research Summary
Scientific consensus: undefined/10.
Consensus: /10MODERATE Evidence
Origins & Manufacturing
Where does fd&c blue #2 lake come from? Let's get nerdy.
How It's Made
Manufacturing process varies by supplier.
What to Look For
✓ Third-party tested✓ GMP certified
Drug & Supplement Interactions
4For You
Is FD&C Blue #2 Lake right for YOU?
Get a personalized verdict based on your health profile.
Products with FD&C Blue #2 Lake
Supplements that contain this ingredient
Medical Disclaimer
This content is for informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any supplement regimen, especially if you have medical conditions or take medications. ARE Supplements does not endorse any specific products.